Drug interactions
Meloxicam + Miconazole vaginal
Severity: Minor
Meloxicam and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP2C9 inhibitor, but vaginal use gives low systemic exposure, so any rise in meloxicam levels is probably small. Case reports of interactions with warfarin suggest systemic absorption can occasionally matter.
What this interaction means in plain words
Meloxicam and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Limited systemic absorption of miconazole may inhibit CYP2C9 metabolism of meloxicam.
What to do
No routine change is needed; monitor for NSAID adverse effects if prolonged or high-dose vaginal therapy is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Miconazole vaginal?
MediHelp rates the interaction as minor. Meloxicam and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole is a CYP2C9 inhibitor, but vaginal use gives low systemic exposure, so any rise in meloxicam levels is probably small. Case reports of interactions with warfarin suggest systemic absorption can occasionally matter.
How serious is the interaction between Meloxicam and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for NSAID adverse effects if prolonged or high-dose vaginal therapy is used.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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