Drug interactions
Meloxicam + Nefazodone
Severity: Moderate
Meloxicam and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity that can impair platelet function, though it is a weaker reuptake inhibitor than SSRIs. Combined with meloxicam, bleeding risk especially in the upper gastrointestinal tract may be increased.
What this interaction means in plain words
Meloxicam and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on platelet aggregation (serotonin uptake inhibition plus COX-1 inhibition) and NSAID mucosal injury.
What to do
Monitor for gastrointestinal bleeding signs and consider gastroprotection in older or high-risk patients. Use the lowest effective NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Nefazodone?
MediHelp rates the interaction as moderate. Meloxicam and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity that can impair platelet function, though it is a weaker reuptake inhibitor than SSRIs. Combined with meloxicam, bleeding risk especially in the upper gastrointestinal tract may be increased.
How serious is the interaction between Meloxicam and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding signs and consider gastroprotection in older or high-risk patients. Use the lowest effective NSAID dose.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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