Drug interactions
Meloxicam + Phenindione
Severity: Major
Meloxicam and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist, and meloxicam impairs platelet function and can cause gastrointestinal ulceration. Together they substantially increase the risk of serious bleeding, and NSAIDs may also displace oral anticoagulants from plasma proteins.
What this interaction means in plain words
Meloxicam and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effects of vitamin K antagonism and NSAID platelet inhibition with mucosal injury, with possible protein-binding displacement.
What to do
Avoid the combination where possible and use paracetamol for analgesia. If unavoidable, monitor INR and signs of bleeding closely and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Phenindione?
MediHelp rates the interaction as major. Meloxicam and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist, and meloxicam impairs platelet function and can cause gastrointestinal ulceration. Together they substantially increase the risk of serious bleeding, and NSAIDs may also displace oral anticoagulants from plasma proteins.
How serious is the interaction between Meloxicam and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol for analgesia. If unavoidable, monitor INR and signs of bleeding closely and consider gastroprotection.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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