Drug interactions
Meloxicam + Prazosin
Severity: Minor
Meloxicam and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam may modestly reduce the blood pressure lowering effect of prazosin, particularly with long-term use.
What this interaction means in plain words
Meloxicam and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meloxicam belongs to Musculoskeletal; Prazosin belongs to Genitourinary.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium retention opposes antihypertensive action.
What to do
Monitor blood pressure when meloxicam is started or stopped and adjust prazosin if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Meloxicam with Prazosin?
MediHelp rates the interaction as minor. Meloxicam and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Meloxicam may modestly reduce the blood pressure lowering effect of prazosin, particularly with long-term use.
How serious is the interaction between Meloxicam and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when meloxicam is started or stopped and adjust prazosin if control is lost.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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