Drug interactions
Meloxicam + Reteplase
Severity: Major
Meloxicam and Reteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase dissolves clots, and meloxicam impairs platelet function and can damage the gastric mucosa. Taken together, the risk of serious bleeding, including gastrointestinal and intracranial hemorrhage, is increased.
What this interaction means in plain words
Meloxicam and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic additive effect of fibrinolysis from reteplase and NSAID-induced platelet dysfunction plus mucosal injury.
What to do
Avoid giving NSAIDs around the time of thrombolysis unless essential, and monitor closely for bleeding in the hours after treatment. Stop meloxicam if clinically significant bleeding occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Reteplase?
MediHelp rates the interaction as major. Meloxicam and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase dissolves clots, and meloxicam impairs platelet function and can damage the gastric mucosa. Taken together, the risk of serious bleeding, including gastrointestinal and intracranial hemorrhage, is increased.
How serious is the interaction between Meloxicam and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving NSAIDs around the time of thrombolysis unless essential, and monitor closely for bleeding in the hours after treatment. Stop meloxicam if clinically significant bleeding occurs.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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