Drug interactions
Meloxicam + Rifampin
Severity: Minor
Meloxicam and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces hepatic enzymes and can reduce meloxicam concentrations. This may lessen pain and anti-inflammatory control, though the effect is typically modest.
What this interaction means in plain words
Meloxicam and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induces CYP2C9 and CYP3A4, increasing the hepatic clearance of meloxicam.
What to do
Monitor clinical response to meloxicam during and after rifampin therapy and increase the dose within the labeled maximum or switch analgesic if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Rifampin?
MediHelp rates the interaction as minor. Meloxicam and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin induces hepatic enzymes and can reduce meloxicam concentrations. This may lessen pain and anti-inflammatory control, though the effect is typically modest.
How serious is the interaction between Meloxicam and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to meloxicam during and after rifampin therapy and increase the dose within the labeled maximum or switch analgesic if needed.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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