Drug interactions
Meloxicam + Sulfamethoxazole
Severity: Minor
Meloxicam and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9, the main enzyme clearing meloxicam, and may raise meloxicam concentrations. This could increase NSAID adverse effects such as gastrointestinal irritation or renal effects, particularly in at-risk patients.
What this interaction means in plain words
Meloxicam and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sulfamethoxazole inhibits CYP2C9-mediated metabolism of meloxicam.
What to do
Monitor for NSAID adverse effects and renal function in patients with risk factors, and use the lowest effective meloxicam dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Sulfamethoxazole?
MediHelp rates the interaction as minor. Meloxicam and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole inhibits CYP2C9, the main enzyme clearing meloxicam, and may raise meloxicam concentrations. This could increase NSAID adverse effects such as gastrointestinal irritation or renal effects, particularly in at-risk patients.
How serious is the interaction between Meloxicam and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects and renal function in patients with risk factors, and use the lowest effective meloxicam dose.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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