Drug interactions
Meloxicam + Sulfasalazine
Severity: Minor
Meloxicam and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is metabolized to a salicylate (5-ASA) and sulfapyridine and its use with meloxicam adds little proven pharmacokinetic risk. Both can irritate the gastrointestinal tract and affect renal function, so additive adverse effects are possible.
What this interaction means in plain words
Meloxicam and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive gastrointestinal and renal effects; no established pharmacokinetic mechanism.
What to do
Usually no change is needed. Monitor for GI symptoms and periodically check renal function and blood counts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Sulfasalazine?
MediHelp rates the interaction as minor. Meloxicam and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is metabolized to a salicylate (5-ASA) and sulfapyridine and its use with meloxicam adds little proven pharmacokinetic risk. Both can irritate the gastrointestinal tract and affect renal function, so additive adverse effects are possible.
How serious is the interaction between Meloxicam and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed. Monitor for GI symptoms and periodically check renal function and blood counts.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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