Drug interactions
Meloxicam + Tenofovir df
Severity: Moderate
Meloxicam and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can impair renal perfusion. Concurrent use, especially with high-dose or multiple NSAIDs, has been associated with acute kidney injury in tenofovir-treated patients.
What this interaction means in plain words
Meloxicam and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction of renal prostaglandin-dependent perfusion adds to tenofovir tubular toxicity and may reduce tenofovir clearance.
What to do
Prefer a non-NSAID analgesic such as paracetamol where possible. If an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meloxicam and Tenofovir df, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Meloxicam with Tenofovir df?
MediHelp rates the interaction as moderate. Meloxicam and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is eliminated by glomerular filtration and active tubular secretion, and NSAIDs can impair renal perfusion. Concurrent use, especially with high-dose or multiple NSAIDs, has been associated with acute kidney injury in tenofovir-treated patients.
How serious is the interaction between Meloxicam and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic such as paracetamol where possible. If an NSAID is needed, use the lowest dose for the shortest time and monitor serum creatinine and phosphate.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
