Drug interactions
Meloxicam + Venlafaxine
Severity: Moderate
Meloxicam and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine inhibits serotonin reuptake into platelets and, combined with an NSAID, increases the chance of bleeding, notably upper gastrointestinal bleeding.
What this interaction means in plain words
Meloxicam and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meloxicam belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Impaired platelet function from serotonin depletion adds to NSAID platelet inhibition and gastric mucosal damage.
What to do
Monitor for bleeding and consider gastroprotection with a proton pump inhibitor in older patients or those with ulcer history. Use paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Meloxicam with Venlafaxine?
MediHelp rates the interaction as moderate. Meloxicam and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine inhibits serotonin reuptake into platelets and, combined with an NSAID, increases the chance of bleeding, notably upper gastrointestinal bleeding.
How serious is the interaction between Meloxicam and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider gastroprotection with a proton pump inhibitor in older patients or those with ulcer history. Use paracetamol where suitable.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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