Drug interactions
Meningococcal group b vaccine + Vincristine
Severity: Moderate
Meningococcal group b vaccine and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy-induced immunosuppression can blunt the antibody response to the vaccine. Protection may be inadequate if the vaccine is given during treatment.
What this interaction means in plain words
Meningococcal group b vaccine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Myelosuppressive and immunosuppressive effects of vincristine reduce the vaccine immune response.
What to do
Where possible, vaccinate at least 2 weeks before chemotherapy or after immune recovery. Consider checking antibody response or revaccinating if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Meningococcal group b vaccine with Vincristine?
MediHelp rates the interaction as moderate. Meningococcal group b vaccine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy-induced immunosuppression can blunt the antibody response to the vaccine. Protection may be inadequate if the vaccine is given during treatment.
How serious is the interaction between Meningococcal group b vaccine and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate at least 2 weeks before chemotherapy or after immune recovery. Consider checking antibody response or revaccinating if given during treatment.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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