Drug interactions
Meprobamate + Oxazepam
Severity: Moderate
Meprobamate and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meprobamate is a sedative-anxiolytic, and combining it with a benzodiazepine increases drowsiness, psychomotor impairment and respiratory depression. Both carry dependence potential.
What this interaction means in plain words
Meprobamate and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A receptor modulation by both drugs.
What to do
Avoid combining where possible, as it duplicates anxiolytic therapy. If used together, use low doses and monitor sedation and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Meprobamate with Oxazepam?
MediHelp rates the interaction as moderate. Meprobamate and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meprobamate is a sedative-anxiolytic, and combining it with a benzodiazepine increases drowsiness, psychomotor impairment and respiratory depression. Both carry dependence potential.
How serious is the interaction between Meprobamate and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, as it duplicates anxiolytic therapy. If used together, use low doses and monitor sedation and respiratory status.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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