Drug interactions
Mestranol + Nilotinib
Severity: Moderate
Mestranol and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may increase systemic exposure to mestranol, a prodrug of ethinylestradiol, by inhibiting CYP3A4 and P-glycoprotein. This could increase estrogenic adverse effects such as nausea, breast tenderness and thromboembolic risk.
What this interaction means in plain words
Mestranol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by nilotinib, reducing the clearance of mestranol.
What to do
Monitor for estrogen-related adverse effects and blood pressure. Consider a lower-estrogen or non-hormonal contraceptive alternative if effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Mestranol with Nilotinib?
MediHelp rates the interaction as moderate. Mestranol and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib may increase systemic exposure to mestranol, a prodrug of ethinylestradiol, by inhibiting CYP3A4 and P-glycoprotein. This could increase estrogenic adverse effects such as nausea, breast tenderness and thromboembolic risk.
How serious is the interaction between Mestranol and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects and blood pressure. Consider a lower-estrogen or non-hormonal contraceptive alternative if effects occur.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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