Drug interactions
Mestranol + Ofloxacin
Severity: Minor
Mestranol and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin has not been shown to meaningfully reduce estrogen levels, and reports of contraceptive failure are rare and not clearly causal. Clinical significance is low.
What this interaction means in plain words
Mestranol and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogen through altered gut flora; not well established.
What to do
No change in contraception is generally required. Advise backup contraception if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Mestranol with Ofloxacin?
MediHelp rates the interaction as minor. Mestranol and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofloxacin has not been shown to meaningfully reduce estrogen levels, and reports of contraceptive failure are rare and not clearly causal. Clinical significance is low.
How serious is the interaction between Mestranol and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in contraception is generally required. Advise backup contraception if vomiting or severe diarrhea occurs.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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