Drug interactions
Mestranol + Tobramycin
Severity: Minor
Mestranol and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral tobramycin could theoretically alter gut flora and affect estrogen recirculation. Tobramycin is usually given parenterally or by inhalation and the evidence for contraceptive failure with antibiotics other than rifamycins is weak.
What this interaction means in plain words
Mestranol and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogen through altered gut flora; not well established.
What to do
No additional contraceptive precautions are routinely needed. Counsel patients to follow usual advice about vomiting or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Mestranol with Tobramycin?
MediHelp rates the interaction as minor. Mestranol and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral tobramycin could theoretically alter gut flora and affect estrogen recirculation. Tobramycin is usually given parenterally or by inhalation and the evidence for contraceptive failure with antibiotics other than rifamycins is weak.
How serious is the interaction between Mestranol and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No additional contraceptive precautions are routinely needed. Counsel patients to follow usual advice about vomiting or diarrhea.
What other medicines interact with Tobramycin?
MediHelp also lists interactions of Tobramycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Tobramycin page.
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