Drug interactions
Mestranol + Tolvaptan
Severity: Minor
Mestranol and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein in vitro and may modestly raise exposure to P-gp substrates. Any rise in mestranol exposure is expected to be small and of limited clinical consequence.
What this interaction means in plain words
Mestranol and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Tolvaptan inhibition of P-glycoprotein efflux, predicted from in vitro data.
What to do
No dose change is required. Be aware of estrogenic adverse effects such as breast tenderness or nausea if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Mestranol with Tolvaptan?
MediHelp rates the interaction as minor. Mestranol and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein in vitro and may modestly raise exposure to P-gp substrates. Any rise in mestranol exposure is expected to be small and of limited clinical consequence.
How serious is the interaction between Mestranol and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Be aware of estrogenic adverse effects such as breast tenderness or nausea if they appear.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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