Drug interactions
Metaproterenol + Phenelzine
Severity: Major
Metaproterenol and Phenelzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine can potentiate the cardiovascular effects of metaproterenol, a beta-agonist, resulting in tachycardia, hypertension and arrhythmia. The interaction is described for MAO inhibitors and sympathomimetic bronchodilators in general.
What this interaction means in plain words
Metaproterenol and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition augments adrenergic stimulation through increased catecholamine availability and additive beta-receptor effects.
What to do
Prefer an alternative bronchodilator regimen; if used, give the lowest effective dose and monitor heart rate, blood pressure and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Metaproterenol with Phenelzine?
MediHelp rates the interaction as major. Metaproterenol and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenelzine can potentiate the cardiovascular effects of metaproterenol, a beta-agonist, resulting in tachycardia, hypertension and arrhythmia. The interaction is described for MAO inhibitors and sympathomimetic bronchodilators in general.
How serious is the interaction between Metaproterenol and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative bronchodilator regimen; if used, give the lowest effective dose and monitor heart rate, blood pressure and ECG.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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