Drug interactions
Metaproterenol + Promethazine
Severity: Minor
Metaproterenol and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no well-established clinical interaction; promethazine sedates while metaproterenol may cause stimulation and tremor. Both can increase heart rate, so tachycardia may be slightly more noticeable.
What this interaction means in plain words
Metaproterenol and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No clear mechanism; opposing CNS effects and possible mild additive tachycardia.
What to do
No specific action is needed beyond monitoring heart rate and symptoms in patients with cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Metaproterenol with Promethazine?
MediHelp rates the interaction as minor. Metaproterenol and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no well-established clinical interaction; promethazine sedates while metaproterenol may cause stimulation and tremor. Both can increase heart rate, so tachycardia may be slightly more noticeable.
How serious is the interaction between Metaproterenol and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring heart rate and symptoms in patients with cardiac disease.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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