Drug interactions
Metaproterenol + Sacubitril-valsartan
Severity: Minor
Metaproterenol and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril-valsartan tends to raise serum potassium whereas metaproterenol, a beta-agonist, can lower it by driving potassium into cells. The net effect is unpredictable, and the clinical relevance is generally small. Beta-agonist hypokalemia may matter at high doses.
What this interaction means in plain words
Metaproterenol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Beta-2 stimulation promotes cellular potassium uptake, while angiotensin receptor blockade reduces aldosterone-mediated potassium excretion; the effects are opposing.
What to do
No routine change needed; check serum potassium if high or frequent doses of metaproterenol are used or in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Metaproterenol with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Metaproterenol and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sacubitril-valsartan tends to raise serum potassium whereas metaproterenol, a beta-agonist, can lower it by driving potassium into cells. The net effect is unpredictable, and the clinical relevance is generally small. Beta-agonist hypokalemia may matter at high doses.
How serious is the interaction between Metaproterenol and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; check serum potassium if high or frequent doses of metaproterenol are used or in patients with renal impairment.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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