Drug interactions
Metaproterenol + Tolvaptan
Severity: Minor
Metaproterenol and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol, a beta-agonist, can lower serum potassium, whereas tolvaptan may raise it, so the effects are opposing. No clinically important interaction is established.
What this interaction means in plain words
Metaproterenol and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on serum potassium; beta-agonists shift potassium into cells while tolvaptan may raise serum potassium.
What to do
No specific action is needed. Check serum potassium if the patient has risk factors or is taking high doses of the beta-agonist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Metaproterenol with Tolvaptan?
MediHelp rates the interaction as minor. Metaproterenol and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metaproterenol, a beta-agonist, can lower serum potassium, whereas tolvaptan may raise it, so the effects are opposing. No clinically important interaction is established.
How serious is the interaction between Metaproterenol and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Check serum potassium if the patient has risk factors or is taking high doses of the beta-agonist.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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