Drug interactions
Metformin + Pasireotide
Severity: Moderate
Metformin and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide frequently causes hyperglycemia and can offset the effect of metformin. Diabetic patients may need additional therapy.
What this interaction means in plain words
Metformin and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Pasireotide suppresses insulin and incretin secretion, opposing metformin's glucose-lowering action.
What to do
Monitor glucose before and during pasireotide therapy and intensify antidiabetic treatment as needed; metformin is often used as first-line management.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Metformin with Pasireotide?
MediHelp rates the interaction as moderate. Metformin and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide frequently causes hyperglycemia and can offset the effect of metformin. Diabetic patients may need additional therapy.
How serious is the interaction between Metformin and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose before and during pasireotide therapy and intensify antidiabetic treatment as needed; metformin is often used as first-line management.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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