Drug interactions
Metformin + Trandolapril
Severity: Minor
Metformin and Trandolapril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance glucose lowering, though hypoglycemia with metformin alone is uncommon. ACE inhibitors can also reduce renal function in susceptible patients, which could raise metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Metformin and Trandolapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Improved insulin sensitivity with ACE inhibition, and possible reduction in renal metformin clearance if renal function declines.
What to do
Monitor blood glucose and renal function when starting trandolapril. Reassess metformin dosing if eGFR falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Metformin
Frequently asked questions
Can I take Metformin with Trandolapril?
MediHelp rates the interaction as minor. Metformin and Trandolapril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may enhance glucose lowering, though hypoglycemia with metformin alone is uncommon. ACE inhibitors can also reduce renal function in susceptible patients, which could raise metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Metformin and Trandolapril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when starting trandolapril. Reassess metformin dosing if eGFR falls.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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