Drug interactions
Metformin + Vandetanib
Severity: Moderate
Metformin and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits the renal organic cation transporter OCT2, which helps eliminate metformin. Metformin exposure may rise, increasing the risk of adverse effects including lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of metformin reduces its clearance.
What to do
Monitor renal function and glycemic control, and watch for gastrointestinal symptoms or signs of lactic acidosis. Reduce the metformin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metformin and Vandetanib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Metformin with Vandetanib?
MediHelp rates the interaction as moderate. Metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits the renal organic cation transporter OCT2, which helps eliminate metformin. Metformin exposure may rise, increasing the risk of adverse effects including lactic acidosis, especially in renal impairment.
How serious is the interaction between Metformin and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glycemic control, and watch for gastrointestinal symptoms or signs of lactic acidosis. Reduce the metformin dose if adverse effects appear.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
