Drug interactions
Metformin-pioglitazone + Methyclothiazide
Severity: Moderate
Metformin-pioglitazone and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and so may blunt the effect of metformin and pioglitazone. Volume depletion or reduced renal function from thiazides may also increase metformin accumulation.
What this interaction means in plain words
Metformin-pioglitazone and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced impairment of glucose tolerance, potassium loss and reduced insulin secretion oppose antidiabetic action, with possible reduced renal clearance of metformin.
What to do
Monitor blood glucose and renal function, and adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Metformin-pioglitazone and Methyclothiazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Metformin-pioglitazone with Methyclothiazide?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and so may blunt the effect of metformin and pioglitazone. Volume depletion or reduced renal function from thiazides may also increase metformin accumulation.
How serious is the interaction between Metformin-pioglitazone and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and adjust the antidiabetic regimen if control worsens.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
