Drug interactions
Metformin-pioglitazone + Mipomersen
Severity: Moderate
Metformin-pioglitazone and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation, and pioglitazone can also cause liver enzyme elevations. Using them together may increase the burden on the liver.
What this interaction means in plain words
Metformin-pioglitazone and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential of both drugs.
What to do
Monitor liver enzymes and bilirubin regularly, and stop the offending drug if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Metformin-pioglitazone with Mipomersen?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation, and pioglitazone can also cause liver enzyme elevations. Using them together may increase the burden on the liver.
How serious is the interaction between Metformin-pioglitazone and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin regularly, and stop the offending drug if significant elevations occur.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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