Drug interactions
Metformin-pioglitazone + Oxymetholone
Severity: Moderate
Metformin-pioglitazone and Oxymetholone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetholone, an anabolic steroid, may enhance the glucose-lowering effect of antidiabetic drugs and increase hypoglycemia risk. Oxymetholone can also cause fluid retention and hepatic toxicity, which may complicate pioglitazone use.
What this interaction means in plain words
Metformin-pioglitazone and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anabolic steroids improve insulin sensitivity and glucose handling, adding to antidiabetic effects.
What to do
Monitor blood glucose and liver function, and reduce antidiabetic doses if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Metformin-pioglitazone with Oxymetholone?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Oxymetholone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxymetholone, an anabolic steroid, may enhance the glucose-lowering effect of antidiabetic drugs and increase hypoglycemia risk. Oxymetholone can also cause fluid retention and hepatic toxicity, which may complicate pioglitazone use.
How serious is the interaction between Metformin-pioglitazone and Oxymetholone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and liver function, and reduce antidiabetic doses if hypoglycemia develops.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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