Drug interactions
Metformin-pioglitazone + Paclitaxel protein bound
Severity: Minor
Metformin-pioglitazone and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is cleared mainly by CYP2C8, and pioglitazone is a weak CYP2C8 inhibitor in vitro. Clinically significant increases in paclitaxel exposure with pioglitazone have not been well demonstrated. Any increase could heighten neutropenia and neuropathy.
What this interaction means in plain words
Metformin-pioglitazone and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP2C8-mediated paclitaxel metabolism by pioglitazone.
What to do
No empirical dose change is needed. Monitor blood counts and neuropathy as per routine paclitaxel care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Metformin-pioglitazone with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is cleared mainly by CYP2C8, and pioglitazone is a weak CYP2C8 inhibitor in vitro. Clinically significant increases in paclitaxel exposure with pioglitazone have not been well demonstrated. Any increase could heighten neutropenia and neuropathy.
How serious is the interaction between Metformin-pioglitazone and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor blood counts and neuropathy as per routine paclitaxel care.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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