Drug interactions
Metformin-pioglitazone + Pitavastatin
Severity: Minor
Metformin-pioglitazone and Pitavastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is not a clinically important OATP1B1 inhibitor, and no meaningful rise in pitavastatin exposure or myopathy has been established. The pairing is commonly used without problems.
What this interaction means in plain words
Metformin-pioglitazone and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-pioglitazone belongs to Endocrine; Pitavastatin belongs to Cardiovascular.
Why it happens
No well-established mechanism; theoretical OATP1B1 inhibition is unlikely to be clinically significant.
What to do
No dose adjustment needed; counsel patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Pitavastatin
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- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Frequently asked questions
Can I take Metformin-pioglitazone with Pitavastatin?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Pitavastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is not a clinically important OATP1B1 inhibitor, and no meaningful rise in pitavastatin exposure or myopathy has been established. The pairing is commonly used without problems.
How serious is the interaction between Metformin-pioglitazone and Pitavastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; counsel patients to report unexplained muscle pain or weakness.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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