Drug interactions
Metformin-pioglitazone + Progesterone intravaginal
Severity: Minor
Metformin-pioglitazone and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic progestogens can reduce insulin sensitivity and modestly raise glucose. With vaginal use, systemic exposure is lower, so any effect on glycemic control is probably small.
What this interaction means in plain words
Metformin-pioglitazone and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone can reduce insulin sensitivity, opposing the effect of antidiabetic drugs.
What to do
Monitor blood glucose when therapy is started or stopped. Adjust antidiabetic doses only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Metformin-pioglitazone with Progesterone intravaginal?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic progestogens can reduce insulin sensitivity and modestly raise glucose. With vaginal use, systemic exposure is lower, so any effect on glycemic control is probably small.
How serious is the interaction between Metformin-pioglitazone and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when therapy is started or stopped. Adjust antidiabetic doses only if control worsens.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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