Drug interactions
Metformin-pioglitazone + Sage
Severity: Minor
Metformin-pioglitazone and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sage has shown glucose-lowering activity in some small studies, so taking it with antidiabetic drugs could add to their effect. The evidence is limited and the effect is probably small.
What this interaction means in plain words
Metformin-pioglitazone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive glucose-lowering effect of sage constituents; the mechanism is not firmly established.
What to do
Advise patients to tell their clinician about sage supplement use and monitor blood glucose if it is taken regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Metformin-pioglitazone with Sage?
MediHelp rates the interaction as minor. Metformin-pioglitazone and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sage has shown glucose-lowering activity in some small studies, so taking it with antidiabetic drugs could add to their effect. The evidence is limited and the effect is probably small.
How serious is the interaction between Metformin-pioglitazone and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to tell their clinician about sage supplement use and monitor blood glucose if it is taken regularly.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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