Drug interactions
Metformin-pioglitazone + Somatropin
Severity: Moderate
Metformin-pioglitazone and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin reduces insulin sensitivity and can raise blood glucose, counteracting metformin and pioglitazone. Antidiabetic doses may need to be increased after growth hormone is started.
What this interaction means in plain words
Metformin-pioglitazone and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-pioglitazone belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through growth hormone-induced insulin resistance.
What to do
Monitor blood glucose after starting or changing the somatropin dose, and adjust the antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Metformin-pioglitazone with Somatropin?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin reduces insulin sensitivity and can raise blood glucose, counteracting metformin and pioglitazone. Antidiabetic doses may need to be increased after growth hormone is started.
How serious is the interaction between Metformin-pioglitazone and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the somatropin dose, and adjust the antidiabetic therapy accordingly.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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