Drug interactions
Metformin-pioglitazone + Tenofovir df
Severity: Moderate
Metformin-pioglitazone and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir DF can cause renal tubular toxicity and decrease renal function, which can reduce metformin elimination. Metformin accumulation raises the risk of lactic acidosis.
What this interaction means in plain words
Metformin-pioglitazone and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir-related renal impairment and possible transporter competition reduce metformin clearance.
What to do
Monitor renal function regularly and reduce or stop metformin if eGFR falls below labeled thresholds. Counsel patients on symptoms of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Frequently asked questions
Can I take Metformin-pioglitazone with Tenofovir df?
MediHelp rates the interaction as moderate. Metformin-pioglitazone and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir DF can cause renal tubular toxicity and decrease renal function, which can reduce metformin elimination. Metformin accumulation raises the risk of lactic acidosis.
How serious is the interaction between Metformin-pioglitazone and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function regularly and reduce or stop metformin if eGFR falls below labeled thresholds. Counsel patients on symptoms of lactic acidosis.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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