Drug interactions
Metformin-repaglinide + Methazolamide
Severity: Moderate
Metformin-repaglinide and Methazolamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methazolamide, a carbonic anhydrase inhibitor, can cause hyperchloremic metabolic acidosis. This may add to the risk of metformin-associated lactic acidosis, particularly in patients with reduced renal function.
What this interaction means in plain words
Metformin-repaglinide and Methazolamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbonic anhydrase inhibition lowers serum bicarbonate and causes acidosis, which adds to the lactic acidosis risk of metformin.
What to do
Monitor serum bicarbonate, renal function and for symptoms of acidosis. Avoid the combination in patients with renal impairment, and stop one of the drugs if acidosis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Methazolamide?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Methazolamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methazolamide, a carbonic anhydrase inhibitor, can cause hyperchloremic metabolic acidosis. This may add to the risk of metformin-associated lactic acidosis, particularly in patients with reduced renal function.
How serious is the interaction between Metformin-repaglinide and Methazolamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum bicarbonate, renal function and for symptoms of acidosis. Avoid the combination in patients with renal impairment, and stop one of the drugs if acidosis develops.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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