Drug interactions
Metformin-repaglinide + Methyclothiazide
Severity: Moderate
Metformin-repaglinide and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effect of antidiabetic drugs, particularly at higher doses. They may also affect renal function, which matters for metformin.
What this interaction means in plain words
Metformin-repaglinide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides impair insulin secretion and glucose tolerance, partly via hypokalemia, opposing the antidiabetic effect.
What to do
Monitor blood glucose and renal function when starting or changing the thiazide dose, and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Methyclothiazide?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effect of antidiabetic drugs, particularly at higher doses. They may also affect renal function, which matters for metformin.
How serious is the interaction between Metformin-repaglinide and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when starting or changing the thiazide dose, and adjust the antidiabetic regimen as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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