Drug interactions
Metformin-repaglinide + Methyltestosterone
Severity: Moderate
Metformin-repaglinide and Methyltestosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens can improve insulin sensitivity and lower blood glucose, which may strengthen the effect of antidiabetic drugs and raise hypoglycemia risk, especially with repaglinide.
What this interaction means in plain words
Metformin-repaglinide and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Androgens may enhance insulin sensitivity, adding to the glucose-lowering effect.
What to do
Monitor blood glucose when starting or stopping methyltestosterone, and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Methyltestosterone?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Methyltestosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens can improve insulin sensitivity and lower blood glucose, which may strengthen the effect of antidiabetic drugs and raise hypoglycemia risk, especially with repaglinide.
How serious is the interaction between Metformin-repaglinide and Methyltestosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping methyltestosterone, and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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