Drug interactions
Metformin-repaglinide + Metronidazole
Severity: Minor
Metformin-repaglinide and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may modestly inhibit CYP-mediated metabolism of repaglinide, potentially raising its levels and increasing hypoglycemia risk. The evidence is limited and the effect is probably small.
What this interaction means in plain words
Metformin-repaglinide and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metformin-repaglinide belongs to Endocrine; Metronidazole belongs to Anti Parasitic.
Why it happens
Weak inhibition of CYP-mediated metabolism of repaglinide.
What to do
Monitor blood glucose during metronidazole therapy and reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Metformin-repaglinide with Metronidazole?
MediHelp rates the interaction as minor. Metformin-repaglinide and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole may modestly inhibit CYP-mediated metabolism of repaglinide, potentially raising its levels and increasing hypoglycemia risk. The evidence is limited and the effect is probably small.
How serious is the interaction between Metformin-repaglinide and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during metronidazole therapy and reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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