Drug interactions
Metformin-repaglinide + Olanzapine
Severity: Moderate
Metformin-repaglinide and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine is associated with weight gain, insulin resistance and hyperglycemia, which can undermine control achieved with metformin and repaglinide. Severe hyperglycemia has been reported.
What this interaction means in plain words
Metformin-repaglinide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Olanzapine promotes insulin resistance and impairs beta-cell function, opposing the effect of antidiabetic drugs.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during olanzapine therapy and intensify antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Olanzapine
Frequently asked questions
Can I take Metformin-repaglinide with Olanzapine?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine is associated with weight gain, insulin resistance and hyperglycemia, which can undermine control achieved with metformin and repaglinide. Severe hyperglycemia has been reported.
How serious is the interaction between Metformin-repaglinide and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during olanzapine therapy and intensify antidiabetic treatment as needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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