Drug interactions
Metformin-repaglinide + Perindopril
Severity: Moderate
Metformin-repaglinide and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients taking antidiabetic drugs. ACE inhibitors may also cause renal function decline, which increases the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Metformin-repaglinide and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
ACE inhibition improves insulin sensitivity, and any resulting reduction in renal function can reduce metformin clearance.
What to do
Monitor blood glucose and renal function, especially after starting therapy or changing the dose, and reassess metformin if eGFR falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Metformin-repaglinide with Perindopril?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and occasionally cause hypoglycemia in patients taking antidiabetic drugs. ACE inhibitors may also cause renal function decline, which increases the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Metformin-repaglinide and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, especially after starting therapy or changing the dose, and reassess metformin if eGFR falls.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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