Drug interactions
Metformin-repaglinide + Phenytoin
Severity: Moderate
Metformin-repaglinide and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP enzymes and may reduce repaglinide exposure, and it can also raise blood glucose by inhibiting insulin release. Glycemic control may worsen as a result.
What this interaction means in plain words
Metformin-repaglinide and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4 and CYP2C8 metabolism of repaglinide and inhibits pancreatic insulin secretion.
What to do
Monitor blood glucose when phenytoin is started or stopped and titrate antidiabetic doses; watch for hypoglycemia after phenytoin withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Metformin-repaglinide with Phenytoin?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces CYP enzymes and may reduce repaglinide exposure, and it can also raise blood glucose by inhibiting insulin release. Glycemic control may worsen as a result.
How serious is the interaction between Metformin-repaglinide and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when phenytoin is started or stopped and titrate antidiabetic doses; watch for hypoglycemia after phenytoin withdrawal.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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