Drug interactions
Metformin-repaglinide + Progesterone intravaginal
Severity: Minor
Metformin-repaglinide and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestogens can modestly impair insulin sensitivity and glucose tolerance, which could slightly reduce the effect of antidiabetic drugs. With vaginal use, systemic exposure is limited and clinically meaningful changes are uncommon.
What this interaction means in plain words
Metformin-repaglinide and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism through progestogen-related reduction in insulin sensitivity.
What to do
Check blood glucose routinely in patients with diabetes who start progesterone, adjusting antidiabetic doses only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Progesterone intravaginal?
MediHelp rates the interaction as minor. Metformin-repaglinide and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestogens can modestly impair insulin sensitivity and glucose tolerance, which could slightly reduce the effect of antidiabetic drugs. With vaginal use, systemic exposure is limited and clinically meaningful changes are uncommon.
How serious is the interaction between Metformin-repaglinide and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose routinely in patients with diabetes who start progesterone, adjusting antidiabetic doses only if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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