Drug interactions
Metformin-repaglinide + Quinapril
Severity: Moderate
Metformin-repaglinide and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and have been associated with hypoglycemia in patients on antidiabetic drugs. Quinapril may also reduce renal function in susceptible patients, which raises the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Metformin-repaglinide and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition may improve insulin sensitivity (pharmacodynamic) and impaired renal function can reduce metformin clearance.
What to do
Monitor glucose, especially at initiation, and check renal function periodically. Hold metformin if acute kidney injury or dehydration develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Quinapril?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and have been associated with hypoglycemia in patients on antidiabetic drugs. Quinapril may also reduce renal function in susceptible patients, which raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Metformin-repaglinide and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, especially at initiation, and check renal function periodically. Hold metformin if acute kidney injury or dehydration develops.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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