Drug interactions
Metformin-repaglinide + Saquinavir
Severity: Moderate
Metformin-repaglinide and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir inhibits CYP3A4 and may increase repaglinide exposure, raising hypoglycemia risk. Protease inhibitors can also induce insulin resistance and hyperglycemia, making control less predictable.
What this interaction means in plain words
Metformin-repaglinide and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition increases repaglinide levels, while protease-inhibitor-related insulin resistance antagonizes glucose lowering.
What to do
Monitor blood glucose closely during co-therapy and adjust repaglinide dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Saquinavir?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir inhibits CYP3A4 and may increase repaglinide exposure, raising hypoglycemia risk. Protease inhibitors can also induce insulin resistance and hyperglycemia, making control less predictable.
How serious is the interaction between Metformin-repaglinide and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-therapy and adjust repaglinide dose as required.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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