Drug interactions
Metformin-repaglinide + Somatropin
Severity: Moderate
Metformin-repaglinide and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity and may raise blood glucose, weakening the effect of metformin and repaglinide. Higher doses carry more risk.
What this interaction means in plain words
Metformin-repaglinide and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-repaglinide belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Growth hormone-induced insulin resistance and increased hepatic glucose output oppose antidiabetic action.
What to do
Monitor glucose when somatropin is started or its dose changed, and increase antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Metformin-repaglinide with Somatropin?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and may raise blood glucose, weakening the effect of metformin and repaglinide. Higher doses carry more risk.
How serious is the interaction between Metformin-repaglinide and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when somatropin is started or its dose changed, and increase antidiabetic therapy as required.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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