Drug interactions
Metformin-repaglinide + St john's wort
Severity: Moderate
Metformin-repaglinide and St john's wort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
St John's wort induces CYP3A4 and can reduce repaglinide concentrations, weakening glycemic control.
What this interaction means in plain words
Metformin-repaglinide and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases repaglinide metabolism.
What to do
Advise patients to avoid St John's wort, or monitor blood glucose and adjust the repaglinide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with St john's wort?
MediHelp rates the interaction as moderate. Metformin-repaglinide and St john's wort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. St John's wort induces CYP3A4 and can reduce repaglinide concentrations, weakening glycemic control.
How serious is the interaction between Metformin-repaglinide and St john's wort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid St John's wort, or monitor blood glucose and adjust the repaglinide dose.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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