Drug interactions
Metformin-repaglinide + Sulfamethoxypyridazine
Severity: Minor
Metformin-repaglinide and Sulfamethoxypyridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials have been associated with hypoglycemia in patients on antidiabetic drugs. The risk is best documented with sulfonylureas, and with repaglinide may be possible via CYP2C8 or protein-binding effects.
What this interaction means in plain words
Metformin-repaglinide and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Not well established; possible additive glucose lowering or displacement from protein binding.
What to do
Counsel on hypoglycemia symptoms and check blood glucose during the antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Sulfamethoxypyridazine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamide antibacterials have been associated with hypoglycemia in patients on antidiabetic drugs. The risk is best documented with sulfonylureas, and with repaglinide may be possible via CYP2C8 or protein-binding effects.
How serious is the interaction between Metformin-repaglinide and Sulfamethoxypyridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on hypoglycemia symptoms and check blood glucose during the antibiotic course.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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