Drug interactions
Metformin-repaglinide + Tenofovir df
Severity: Moderate
Metformin-repaglinide and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir may modestly raise metformin exposure, and both drugs are eliminated through the kidney. In patients with reduced renal function this could contribute to metformin accumulation and, rarely, lactic acidosis.
What this interaction means in plain words
Metformin-repaglinide and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible competition for renal tubular secretion transporters (OCT2/MATE) reduces metformin clearance, with tenofovir nephrotoxicity as an additional contributor.
What to do
Monitor serum creatinine and eGFR regularly and reduce or stop metformin if renal function declines. Counsel patients to report symptoms of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Tenofovir df?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir may modestly raise metformin exposure, and both drugs are eliminated through the kidney. In patients with reduced renal function this could contribute to metformin accumulation and, rarely, lactic acidosis.
How serious is the interaction between Metformin-repaglinide and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and eGFR regularly and reduce or stop metformin if renal function declines. Counsel patients to report symptoms of lactic acidosis.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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