Drug interactions
Metformin-repaglinide + Triamcinolone acetonide injectable
Severity: Moderate
Metformin-repaglinide and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injected triamcinolone can raise blood glucose for days to weeks, counteracting antidiabetic therapy. Patients with diabetes may develop marked hyperglycemia after a dose.
What this interaction means in plain words
Metformin-repaglinide and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroids increase gluconeogenesis and insulin resistance, opposing the glucose-lowering action of metformin and repaglinide.
What to do
Increase blood glucose monitoring for one to several weeks after injection and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injected triamcinolone can raise blood glucose for days to weeks, counteracting antidiabetic therapy. Patients with diabetes may develop marked hyperglycemia after a dose.
How serious is the interaction between Metformin-repaglinide and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring for one to several weeks after injection and adjust antidiabetic therapy if needed.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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