Drug interactions
Metformin-repaglinide + Trifluoperazine
Severity: Minor
Metformin-repaglinide and Trifluoperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can impair glucose tolerance and may reduce the effectiveness of antidiabetic drugs. The effect is generally modest but can cause loss of glycemic control.
What this interaction means in plain words
Metformin-repaglinide and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Antipsychotic-related insulin resistance and reduced insulin secretion may oppose glucose lowering; the mechanism is not well established.
What to do
Monitor blood glucose when trifluoperazine is started, changed or stopped, and adjust antidiabetic doses if required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Trifluoperazine?
MediHelp rates the interaction as minor. Metformin-repaglinide and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics can impair glucose tolerance and may reduce the effectiveness of antidiabetic drugs. The effect is generally modest but can cause loss of glycemic control.
How serious is the interaction between Metformin-repaglinide and Trifluoperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trifluoperazine is started, changed or stopped, and adjust antidiabetic doses if required.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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