Drug interactions
Metformin-repaglinide + Xipamide
Severity: Moderate
Metformin-repaglinide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics such as xipamide can raise blood glucose and impair glucose tolerance, weakening antidiabetic therapy. Volume depletion and reduced renal function may also raise metformin accumulation risk.
What this interaction means in plain words
Metformin-repaglinide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced hypokalemia and insulin resistance raise glucose, and volume depletion may reduce metformin renal clearance.
What to do
Monitor blood glucose, potassium and renal function, and adjust antidiabetic doses as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Metformin-repaglinide with Xipamide?
MediHelp rates the interaction as moderate. Metformin-repaglinide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-like diuretics such as xipamide can raise blood glucose and impair glucose tolerance, weakening antidiabetic therapy. Volume depletion and reduced renal function may also raise metformin accumulation risk.
How serious is the interaction between Metformin-repaglinide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and renal function, and adjust antidiabetic doses as required.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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