Drug interactions
Metformin-sitagliptin + Moexipril
Severity: Moderate
Metformin-sitagliptin and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and occasionally lead to lower blood glucose in people on antidiabetic drugs. A decline in renal function from the ACE inhibitor can reduce metformin elimination and raise lactic acidosis risk.
What this interaction means in plain words
Metformin-sitagliptin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metformin-sitagliptin belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
Additive glucose lowering through enhanced insulin sensitivity, plus possible reduced renal metformin clearance if renal function declines.
What to do
Monitor glucose and renal function after starting or changing the dose. Reduce or stop metformin-sitagliptin if renal function worsens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Metformin-sitagliptin with Moexipril?
MediHelp rates the interaction as moderate. Metformin-sitagliptin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and occasionally lead to lower blood glucose in people on antidiabetic drugs. A decline in renal function from the ACE inhibitor can reduce metformin elimination and raise lactic acidosis risk.
How serious is the interaction between Metformin-sitagliptin and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function after starting or changing the dose. Reduce or stop metformin-sitagliptin if renal function worsens significantly.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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